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Cervical cancer

Cervical cancer develops if the cells of your cervix (the neck of your womb) become abnormal and grow out of control.

Around 3,400 women in the UK are diagnosed with cervical cancer every year. However, cervical cancer is one of the few preventable cancers. 

Deaths from cervical cancer in the UK have fallen over the last 25 years. This reduction is mainly because of the NHS cervical screening programme which detects changes in the cells of your cervix at a pre-cancerous stage. If abnormal cells are caught early, cancer can be prevented. 

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How cancer develops
Cells begin to grow in an uncontrolled way
Image showing the cervix and transformation zone

Details

  • Types Types of cervical cancer

    There are two main types of cervical cancer – squamous cell cancer (the most common) and adenocarcinoma, although they are often mixed. They are named after the types of cell that become cancerous. Squamous cells are flat cells covering your cervix; adenomatous cells are found in the passageway from your cervix to your womb. Other rarer cancers of the cervix include small cell cancer.

  • Symptoms Symptoms of cervical cancer

    If your smear detects abnormal cells on your cervix, they are usually at an early pre-cancer stage, and don't cause any symptoms. Treating the abnormal cells prevents cancer developing.

    If abnormal cells do develop into cervical cancer, you may have the following symptoms:

    • abnormal vaginal bleeding, for example between periods or after sex
    • smelly vaginal discharge
    • pain during sex
    • vaginal bleeding after the menopause
    • pain in your pelvis

    These symptoms aren't always due to cervical cancer but if you have them, see your GP.

  • Diagnosis Diagnosis of cervical cancer

    If you have had an abnormal screening result, or have symptoms of cervical cancer, your doctor will refer you to a gynaecologist (a doctor who specialises in women’s reproductive health).

    You may have a number of tests including the following.

    • A colposcopy – your doctor uses a lighted magnifying instrument called a colposcope to examine your cervix. He or she will take a small sample of tissue (a biopsy) to be sent to a laboratory for testing to see if the abnormal cells have spread.
    • LLETZ (large-loop excision of the transformation zone) or loop diathermy – your doctor uses a loop of wire with an electrical current passing through it to remove the abnormal cells which are then sent to a laboratory for testing.
    • A cone biopsy – your doctor will take a cone of your cervix tissue under general anaesthesia. The sample will be sent to a laboratory for testing.
    • A CT, MRI, PET or ultrasound scan – to check your health and show how far the cancer has spread (if at all).

    If you’re pregnant, it’s safe for you to have a colposcopy. If your doctor finds any pre-cancerous cells, treatment can normally wait until after your baby has been born. If your doctor suspects you have cancer, you may have a cone biopsy, although this can cause a miscarriage and affect future pregnancies. The results will show the stage of your cervical cancer and how far it has spread.

  • Treatment Treatment of cervical cancer

    Your treatment will depend on the stage of your cervical cancer and your general health. You may have a combination of treatments. Your surgeon or oncologist will advise you which treatment is best for you.

    Surgery

    If you have very early stage cervical cancer, a cone biopsy may be all you need.

    The most common surgical treatment for cervical cancer is a hysterectomy, including removal of the top few centimetres of your vagina and the lymph nodes in your pelvis.

    If you have early stage cancer and you want to have more children, a radical trachelectomy might be possible. Your surgeon will remove most of your cervix but leave the opening behind, so that you can still have a baby.

    Radiotherapy

    Radiotherapy is a treatment to destroy cancer cells with radiation. A beam of radiation is targeted on the cancerous cells, which shrinks the tumour. You may have only radiation, or you may have radiation after surgery.

    You may have radiation combined with chemotherapy if the cancer is more advanced or has spread to other areas. This reduces the risk of the cancer coming back. Radiotherapy can be given either from outside the body (external beam radiotherapy) or internally (brachytherapy). You will usually have external radiotherapy followed by internal radiotherapy.

    Chemotherapy

    Chemotherapy is a treatment to destroy cancer cells with medicines. It’s used with radiotherapy, or to help to shrink a tumour before radiotherapy or surgery. It can also control symptoms if cancer comes back after an initial treatment.

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  • Causes Causes of cervical cancer

    The main cause of cervical cancer is the human papilloma virus (HPV). There are over 100 different types, or strains, of HPV and each type has a specific number. Some types of HPV cause warts and verrucas, and others increase the risk of cervical and other types of cancer.

    You may have caught this common virus through sex and be unaware that you have it as it usually causes no symptoms. Your immune system may get rid of the infection so you may never be aware of it. Only a very small proportion of women with HPV will develop cervical cancer.

    Although HPV is from the same family as the virus that causes genital warts, having genital warts doesn’t make you more likely to develop cervical cancer. Cervical cancer is caused by a different type of HPV.

    To reduce the number of women developing cervical cancer, vaccinations to protect against HPV have been developed. Since 2008, in the UK, there has been a national programme of vaccination for girls aged 12 to 13.

    Risk factors of cervical cancer include:

    • smoking
    • having sex at an early age
    • having other sexually transmitted infections such as chlamydia and herpes
    • having many sexual partners, or a partner who has had many partners
    • taking the contraceptive pill long-term
    • having a weakened immune system
  • Prevention Prevention of cervical cancer

    The following steps may help to reduce your risk of cervical cancer.

    • Condoms – using these during sex gives you some protection.
    • Regular smears – these are part of the NHS cervical screening programme and can detect pre-cancerous cells in your cervix. If you're aged between 25 and 49 and live in England, you will be invited for a smear every three years; the invitation will be every five years if you’re aged between 50 and 64. The exact age groups for screening vary between different UK counties.
    • HPV vaccine – girls aged between 12 and 13 across the UK are now offered a vaccine which protects against the HPV strains most likely to cause cervical cancer. A three-year catch-up programme to vaccinate girls under 18 began in 2009.
  • Help and support Help and support

    Being diagnosed with cancer can be distressing for you and your family. An important part of cancer treatment is having support to deal with the emotional aspects as well as the physical symptoms. Specialist cancer doctors and nurses are experts in providing the support you need, and may also visit you at home. If you have more advanced cancer, further support is available to you in hospices or at home, and this is called palliative care.

  • FAQs FAQs

    Will treatment for cervical cancer affect my sex life?

    Answer

    It's usually safe to start having sex again within a few weeks of finishing radiotherapy or having surgery for cervical cancer, depending on the exact treatment you have had. However, treatment for cervical cancer may cause an early menopause and radiotherapy can cause side-effects that can affect your sex life.

    Explanation

    If you haven't yet had your menopause, radiotherapy or surgery to remove your womb and ovaries (hysterectomy) will cause an early menopause. The symptoms are the same as those of a natural menopause. These include:

    • hot flushes and sweating
    • a dry vagina
    • low mood
    • tiredness
    • loss of interest in sex

    Your GP may prescribe hormone replacement therapy (HRT) or other medicines to help with these symptoms. Topically applied gels and creams may help if you have a dry vagina.

    Radiotherapy may also cause a narrowing of your vagina, a dry vagina and pain during sex. Talk to your GP about how to manage these symptoms.

    You may want to use condoms if you’re having chemotherapy just as a precaution. This is because doctors don’t know whether these medicines can pass to your partner though your vaginal or cervical mucus.

    Finally, treatment may make you feel anxious about having sex again and you may not feel like doing so until you have come to terms with your illness.

    Will I still need cervical screening tests if I have had the human papilloma virus (HPV) vaccine?

    Answer

    Yes, if you have had the human papilloma virus (HPV) vaccine you will still need regular cervical screening tests.

    Explanation

    There are many different types of HPV. They can be divided into those that are associated with an increased risk of developing certain types of cancer and those that aren't. The HPV vaccine doesn't protect against all types of HPV that are associated with cervical changes and cancer. Therefore, the vaccines don't provide complete protection against the disease. It's thought that the vaccines will prevent at least seven out of 10 of the most common type of cervical cancer (squamous cell cancer).

    Therefore, it's important to attend routine cervical screening appointments even if you have had the HPV vaccine.

    Does human papilloma virus (HPV) cause cancer in men?

    Answer

    Yes, the human papilloma virus (HPV) is associated with cancer of the penis, anus, and head and neck (tonsils, tongue, and the area at the back of the throat, known as the pharynx).

    Explanation

    HPV is a common virus that can be passed on through sex but doesn't usually cause symptoms. There are over 100 types of HPV – some of these can cause genital warts and some types increase the risk of developing a particular cancer and are called 'high-risk' HPV. Your immune system usually removes the virus from your body, or the virus can remain in your body without causing any harm for a long time.

    High-risk HPV may be a cause of cancer of the penis. Penile cancer is rare in the UK, but it's important to be aware of the symptoms. These include:

    • a change in the colour, or a thickening, of the skin of your penis
    • discharge or bleeding from your penis
    • growths or sores, especially under your foreskin

    High-risk HPV can cause changes in the cells around your anus. These changes may develop into anal cancer after many years. Anal cancer is rare in the UK but it's important to be aware of the symptoms. These include:

    • bleeding from your rectum (back passage)
    • pain, discomfort, and itching around your anus
    • small lumps around your anus
    • faecal incontinence

    High-risk HPV may be linked to cancers affecting your tonsils, tongue and pharynx (the area at the back of your throat). This type of HPV virus is most likely transmitted during oral sex.
    Symptoms of head and neck cancer include:

    • an ulcer that doesn't heal
    • difficult or painful swallowing
    • pain when you chew
    • a constant sore throat
    • a lump in your mouth
    • numbness in your mouth or lips

    If you have any of the symptoms listed above, they might not be due to cancer, but if you have them, see your GP.

  • Resources Resources

    Further information

    Sources

    • Cervical cancer. Cancer Research UK. www.cancerresearchuk.org, published June to September 2012
    • Cervical cancer and HPV. Prodigy. www.prodigy.clarity.co.uk, published December 2010
    • HPV vaccines. Cancer Research UK. www.cancerresearchuk.org, published September 2012
    • How chemotherapy may affect your sex life. Macmillan Cancer Support. www.macmillan.org.uk, published June 2010
    • HPV and cancer. Macmillan Cancer Support. www.macmillan.org.uk, published December 2010
    • Early menopause after pelvic radiotherapy. Macmillan Cancer Support. www.macmillan.org.uk, published July 2012
    • Cervical cancer. Macmillan Cancer Support. www.macmillan.org.uk, published April 2012
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    Produced by Dylan Merkett, Bupa Health Information Team, March 2013.

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