Many women don’t have any symptoms or only have vague symptoms in the early stages of ovarian cancer. Many of these symptoms can occur in other conditions as well and aren’t necessarily a sign of cancer. If you do have symptoms, they may include:
- stomach pain or pain in your pelvis
- a swollen abdomen and persistent bloated feeling
- feeling full quickly and losing your appetite
- needing to pass urine more often or more urgently
Other possible symptoms include:
- unexplained weight loss
- changes in your bowel bladder habit, such as constipation, excess wind or diarrhoea
- back pain
- extreme tiredness
- rarely, abnormal bleeding from your vagina
If you have any of these symptoms, see your GP. The earlier you’re diagnosed, the better your chance of survival so it's important to discuss any concerns with your GP.
Your GP will ask you about your symptoms and examine you. He or she may also ask you about your medical history and whether anyone else in your family has had breast or ovarian cancer.
Your GP will ask you to have a blood test to check the levels of certain proteins, such as CA125, that can be high if you have ovarian cancer. He or she may also examine you internally to check your womb and ovaries.
Your GP may organise some further tests, such as an ultrasound scan to view the inside of your abdomen and pelvis. Your GP may do the ultrasound or you may need to go to hospital to have this. You may also have a CT scan at a hospital.
Your GP may refer you to a gynaecologist (a doctor who specialises in women’s reproductive health).
If you’re found to have cancer, you will need to have more tests to assess if the cancer has spread outside your ovaries. This process of finding out whether the cancer has spread is called staging. This is important because it can help doctors to estimate how your cancer is likely to progress, and what the best course of treatment will be.
Further tests may include a gynaecological laparoscopy – this is a procedure used to examine your fallopian tubes, ovaries and womb. You may also have a small sample of tissue taken (a biopsy), which will be sent to a laboratory for testing. If you have a build-up of fluid in your stomach, it can be drawn out through a needle and examined to see whether cancer cells are present. This is known as abdominal fluid aspiration or paracentesis.
Your treatment will depend on the type of ovarian cancer you have and how far it has spread. It will also depend on your general state of health, whether you plan to have children and other issues personal to you.
Most women with ovarian cancer have a combination of surgery and chemotherapy. Your doctor may give you information on clinical trials that are testing new treatments for ovarian cancer.
Almost all women with ovarian cancer need surgery. If the cancer hasn't spread beyond your ovary, it may be possible to remove just your single affected ovary and fallopian tube.
If the cancer has already spread beyond your ovary, you may need to have both ovaries and your womb, together with nearby lymph nodes and surrounding tissue removed. This is called a total abdominal hysterectomy and bilateral salpingo-oophrectomy, or a TAH and BSO for short.
Other types of surgery for more advanced ovarian cancer are used to remove, or 'debulk' as much of the tumour as possible before you have chemotherapy.
Chemotherapy uses medicines to destroy cancer cells. The type of chemotherapy treatment you have will vary depending on your type of ovarian cancer. A common type of chemotherapy medicine is carboplatin, which you can have alone or in combination with another medicine, called paclitaxel. However, there are lots of other chemotherapy medicines available. Usually you have a course of treatment, which will involve having several doses at regular intervals over a period of weeks. Your doctor will give you information on the type and course that is best for you.
You will probably be offered chemotherapy after surgery to destroy any remaining cancer cells that weren’t removed by surgery or if there is a risk the cancer may return. However, you may also have chemotherapy before surgery to shrink your tumour.
If ovarian cancer comes back (a relapse), you may be treated with the same chemotherapy medicine or an alternative one. This will depend on the timing of your relapse and whether the cancer has developed resistance to previous chemotherapy medicines.
Radiotherapy uses radiation to destroy cancer cells. It's not often used to treat ovarian cancer but is very occasionally used after surgery to destroy any remaining cancer cells.
You will need to attend hospital appointments and have regular check-ups after your treatment to see if any of the cancer remains. If further cancer is found, you may be able to have more treatment to remove it.
The exact reasons why you may develop ovarian cancer aren't fully understood at present. However, there are some things that can make it more likely. It's more common in women who live in developed countries for example, and in those who have gone through the menopause. It’s also known that inheriting faulty genes called BRCA1 and BRCA2 increase the risk of ovarian cancer.
Other factors that may increase your risk of getting ovarian cancer include:
- certain types of hormone replacement therapy (HRT) – especially if you take them for longer than five years
- being overweight or obese
- having endometriosis or ovarian cysts
- starting the menopause late
Ovarian cancer is generally less common in women who have:
- used the contraceptive pill
- had children – the more children, the lower the risk
- breastfed their children
- had a hysterectomy or been sterilised
You may be able to reduce your risk of developing some types of ovarian cancer by making changes to your lifestyle, such as stopping smoking and eating a healthy, balanced diet. If you take an oral contraceptive, it can also reduce your risk.
If you have a strong family history of breast or ovarian cancer, for example if your mother or aunt had cancer when she was under 50, let your GP know. He or she may refer you to a genetic service. This service can assess your own risk and if it's high, your GP can monitor you and diagnose and treat any cancer early.
Being diagnosed with cancer can be distressing for you and your family. An important part of cancer treatment is support to deal with the emotional aspects as well as the physical symptoms. Specialist cancer doctors and nurses are experts in providing the support you need. If you have more advanced cancer, further support is available to you in hospices or at home – this is called palliative care.
Are there any ovarian cancer screening programmes I can attend?
No, there isn't a national ovarian cancer screening programme because tests to spot early ovarian cancer cells aren't effective enough yet. But your GP can refer you to a local genetics service (also known as a family cancer clinic) for screening if you're at a high risk.
Research is being carried out in a 10-year study called the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) to find reliable tests that may lead to a screening programme. Some 200,000 women are taking part in the trial to see if routine blood tests and ultrasound scans can detect early ovarian cancer. Initial results are encouraging and suggest that these tests could be used on a large scale to identify ovarian cancer. Final results from the study are expected in 2015.
If you have two relatives from the same side of your family who were diagnosed with ovarian cancer or breast cancer under the age of 50, you may be considered high-risk. Your GP can refer you to a local genetics service where your risk will be assessed and you will be given information and advice.
How can ovarian cancer come back after I have had surgery?
The aim of surgery is to remove as much of the cancer as possible. It may be possible to remove all of the cancer but sometimes some of the cancer may be left behind.
It’s still possible for ovarian cancer to come back even if you have had an operation to remove your ovary. Ovarian cancer may have spread beyond your ovary by the time it’s diagnosed so even if you had it removed, some cancer cells may already have spread into other parts of your body.
The aim of surgery is to remove as much cancer as possible. However, residual ‘seedlings’ of cancer cells can often be unavoidably left behind after surgery. The amount of cancer left after surgery varies between women. It may be only a few cells but can be larger amounts.
You may have chemotherapy after your operation as this can help to destroy any remaining cancer cells. Chemotherapy is often able to kill off the majority of cancer cells and the cancer is then in ‘remission’. If all the detectable cancer disappears, it’s called ‘complete remission’. If most of the cancer disappears but a small amount remains, it’s known as ‘partial remission’. Sometimes the cancer cells resist the effects of chemotherapy and the disease doesn’t improve. Your doctor will then discuss alternative treatments with you.
It’s important to attend hospital appointments after your operation and have regular tests to see if any of the cancer remains. If further cancer is found, you may be able to have more treatment to remove it.
If you have any questions about your surgery and what results you can expect from it, ask your surgeon or doctor for advice.
I've heard that using talcum powder causes ovarian cancer, is this true?
It’s possible that talcum powder may increase your risk of getting ovarian cancer but at present the research is inconclusive. More research is needed to prove if talc can cause ovarian cancer.
There is a theory that talc may be able to travel up your vagina through your cervix to your womb, fallopian tubes and ovaries. This could potentially cause your ovaries to become irritated and inflamed, which may lead to cancerous changes in the cells.
Some studies found that women who used talcum powder on their genitals were at a slightly higher risk of getting ovarian cancer than those who didn't. However, the studies and the results are not considered to be very reliable and the slight increase could have been a chance result.
Other research found an increased risk of ovarian cancer in women who regularly use talc – and the risk increased with heavier use of talc. However, further research is needed to get a decisive answer. If you have any questions about the latest research, ask your doctor.
Why are women who take the contraceptive pill or have children less likely to develop ovarian cancer?
Doctors believe that ovarian cancer is related to the number of times you ovulate (release one or more eggs from one of your ovaries) in your life. So the fewer ovulation cycles you have, the lower your risk of ovarian cancer. You ovulate during each menstrual cycle, several days before your period.
Research has shown that taking the contraceptive pill at some point in your life reduces your chances of getting ovarian cancer. The longer you take it for, the lower your risk becomes. Once you stop taking the contraceptive pill, it carries on protecting you from ovarian cancer for at least 20 years.
Having been pregnant – even if you had a miscarriage or an abortion – reduces your risk of developing ovarian cancer. The more children you have, the lower your risk of developing ovarian cancer. Some research suggests that this is also related to the age you are when you have your last child. For example if you have your last child after the age of 35, you're more protected than if you have your last child before the age of 25.
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