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Genetic factors increase risk of Parkinson's disease10 August 2006 Genetics may play a part in the risk of developing Parkinson's disease, according to new research. After completing one of the largest studies of its kind, scientists at the Mayo Clinic in the US have found strong evidence to suggest that certain genes passed down from parents may contribute to the cause of Parkinson's disease. Little is known about the causes of the disease, which affects the brain, producing symptoms such as tremors, slowness of movement and stiffness or rigidity of muscles. The team from the Mayo Clinic analysed data from 2,692 Parkinson's disease patients and 2,652 healthy individuals and found that those carrying a mutation causing higher levels of activity of a gene called alpha-synuclein had a one and a half times greater risk of developing the disease. Dr Demetrius Maraganore, lead author of the study published in the Journal of the American Medical Association (JAMA), said that the results provide "compelling evidence" for the development of therapies to counteract the gene. More information
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